Animal, test-tube, and human studies have indicated that sulforaphane may offer a number of health benefits. May Have Anticancer Effects Our Broccoli Sprout does contain activated Sulforaphane. An enzyme is used in this extraction process so it is effectively already "activated" and stable for use by the body. We are not aware of any intolerances, but we cannot rule out individual intolerances. Please adhere to our Myrosinase enzymes are only released and activated when a plant is damaged. Therefore, cruciferous vegetables must be cut, chopped, or chewed to release myrosinase and activate sulforaphane ( 1).

Foundational Medicine Review. Sulforaphane glucosinolate monograph. Alt Med Rev. 2010;15(4):352-360. AHA Journals. (1997). Phytochemicals and cardiovascular disease. [Online]. AHA Journals. Last Updated: 1997. Available at: https://www.ahajournals.org/doi/full/10.1161/01.cir.95.11.2591 [Accessed 6 December 2022]. Current epidemiological evidence suggests that cruciferous vegetables play a key role in muscle and bone health, possibly due to the presence of glucosinolates and isothiocyanates. For example, in a large cohort of older community-dwelling women ( n= 1,468, ≥70years), women with the highest cruciferous (>44g/day) and allium (>11g/day) vegetable intake had 28 and 34% lower relative hazards for a fracture-related hospitalization over 14.5years, respectively ( Blekkenhorst et al., 2017b). Similarly, greater cruciferous and allium vegetable intake was associated with 22 and 26% lower relative hazard ratio for an injurious fall-related hospitalization over this time, respectively ( Sim et al., 2018). Although not specifically examining the role of glucosinolates, these studies demonstrate the potential importance of a diet rich in glucosinolates for musculoskeletal health. Muscle Jiang X, Liu Y, Ma L, et al. Chemopreventive activity of sulforaphane. Drug Des Devel Ther. 2018;12:2905-2913. doi:10.2147/DDDT.S100534The salary of LB is supported by a National Health and Medical Research Council of Australia Emerging Leadership Investigator Grant (ID: 1172987) and a National Heart Foundation of Australia Post-Doctoral Research Fellowship (ID: 102498). EC is supported by an Australian Government Research Training Program Scholarship at Edith Cowan University. WM is currently funded by an Alfred Deakin Postdoctoral Research Fellowship and a Multiple Sclerosis Research Australia early-career fellowship. The salary of MS is supported by a Royal Perth Hospital Research Foundation Career Advancement Fellowship (ID: 00/2020). GB is supported by the Big C Scientific/Clinical Research Grant 11-13R. The salary of JL is supported by a National Heart Foundation of Australia Future Leader Fellowship (ID: 102817). The salary of JH is supported by a National Health and Medical Research Council of Australia Senior Research Fellowship (Grant number 1116973). Conflict of Interest It’s best to cook the vegetables below 284˚F (140˚C), as exceeding this temperature results in a loss of glucosinolates like glucoraphanin ( 4).

May protect against sun damage. Studies suggest that sulforaphane may protect against ultraviolet (UV) skin damage caused by the sun ( 21, 22, 23). Yanaka A. Daily intake of broccoli sprouts normalizes bowel habits in human healthy subjects. J Clin Biochem Nutr. 2018;62(1):75-82. doi:10.3164/jcbn.17-42Alumkal JJ, Slottke R, Schwartzman J, et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs. 2015;33(2):480-489. doi:10.1007/s10637-014-0189-z To optimize your intake of sulforaphane, eat vegetables raw or cooked at temperatures below 284˚F (140˚C) ( 4).

The most characteristic feature of sulforaphane is its high chemical reactivity due to the electrophilicity of the central carbon of the isothiocyanate (—N WM has previously received funding from the NHMRC, Clifford Craig Foundation, Cancer Council Queensland and university grants/fellowships from La Trobe University, Deakin University, University of Queensland, and Bond University, received industry funding and has attended events funded by Cobram Estate Pty. Ltd., received travel funding from Nutrition Society of Australia, received consultancy funding from Nutrition Research Australia, and has received speakers honoraria from The Cancer Council Queensland and the Princess Alexandra Research Foundation. NT has received funding from Deakin University for an Executive Dean’s Post-Doctoral Fellowship. for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia

What Are Broccoli Sprouts?

Tahata S, Singh SV, Lin Y, Hahm ER, et al. Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients with multiple atypical nevi. Cancer Prev Res (Phila). 2018;11(7):429-438. doi:10.1158/1940-6207.CAPR-17-0268 Treatment with sulforaphane significantly reduced migration and adhesion and inhibited expression of key molecules in angiogenesis, VEGF, STAT3, and HIF-1 α, in liver cancer cell line, HepG2 ( Liu et al., 2017). Sulforaphane exposure led to reduction in cell growth, by significantly downregulating key cell cycle-related genes in HepG2 and Huh7 cell lines, and also within a xenograft mouse model ( Sato et al., 2018). Sulforaphane decreased secretion of the pro-inflammatory cytokine, interleukin-6, and was not linked with cellular toxicity in HepG2 cells ( Al-Bakheit and Abu-Qatouseh, 2020), suggesting that sulforaphane could have anti-inflammatory properties and may modulate liver carcinogenesis.

Klomparens EA, Ding Y. The neuroprotective mechanisms and effects of sulforaphane. Brain Circ. 2019;5(2):74-83. doi:10.4103/bc.bc_7_19 Development of proactive prevention programs, e.g., preventive, predictive, personalized and participatory (“P4”), are emerging as important elements to control a number of chronic, degenerative diseases. The transformation of cancer prevention through personalized or precision medicine is a prime example of current opportunity ( Kensler etal., 2016), although any one of the P4 elements alone will not be sufficient. Within the context of cancer, much of the expanding global burden will occur in the developing and recently developed countries. Many in these regions, and arguably most regions, will have neither access nor ability to afford the latest generation of molecular-targeted pharmaceuticals. By contrast, implementation programs for tobacco control, vaccination, screening, as well as public health programs promoting physical activity and consumption of healthier diets will have greater impact on population health broadly and cancer prevention specifically. Access to local foodstuffs containing bioactive phytochemicals may offer a frugal or “green” ( Fahey, Talalay, & Kensler, 2012a) means for accelerating disease prevention. Appreciation of the mechanisms of the action of such phytochemicals will facilitate the utilization of indigenous protective foods or perhaps guide the introduction of culturally appropriate new foods into their diets. Those with type 2 diabetes can’t effectively transport sugar from their blood to their cells, making it difficult to maintain healthy blood sugar levels. Given the positive actions of glucosinolates are largely related to anti-inflammatory and antioxidant mechanisms, the consumption of cruciferous vegetables and their glucosinolates may also have beneficial outcomes on other health conditions. Although there are few studies investigating the impact of certain cruciferous vegetables on other chronic conditions, such as obesity, future studies are needed to further investigate the role of glucosinolates. Author Contributions The type of glucosinolate determines the compounds formed; different sidechains result in the production of different end products ( Barba et al., 2016). More than 130 glucosinolates have been identified ( Blažević et al., 2020), although not all are found in plants commonly consumed by humans. Glucosinolates have been commonly classified under three categories: Aliphatic, indole, and aromatic glucosinolates. However, this classification has also been disputed in a recent review where the type of degradation end product was proposed to be a more useful classification method ( Blažević et al., 2020).Try steaming broccoli for a few minutes to soften it and bring out a sweeter flavor. You can also mix it with other vegetables for a nutrient boost.